Stem Cell Research

Lentiviral Vectors Effective For Genetic Modification

Published in Gene Therapy Weekly, January 31st, 2002

by Michael Greer, senior medical writer - Researchers in the United States have shown that hematopoietic stem cells can be effectively engineered using lentiviral vectors.

"Hematopoietic stem cells (HSCs) represent an important target for the treatment of various blood disorders," explained Yan Cui and colleagues at Johns Hopkins University's Johns Hopkins Oncology Center in Baltimore, Maryland. "As the source of critical cells within the immune system, genetic modification of HSCs can also be used to modulate immune responses."

Self-inactivating (SIN) lentiviral vectors can be used to transfect stem cells, and can target transgene expression to...

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Source: Gene Therapy Weekly (2002-01-31)

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