Gene Transport

Plasmid Vectors Deliver Genes Better With Electroporation

Published in Gene Therapy Weekly, February 21st, 2002

by Sonia Nichols, senior medical writer - The delivery of genes to multiple layers of corneal tissues can be accomplished more thoroughly with plasmid vectors when electroporation is used.

In electroporation, electric pulses are locally applied to targeted tissues, forcing cells within those tissues to open for a moment. Scientists at Northwestern University in Chicago, Illinois, and the University of South Alabama in Mobile say electroporation allows for better gene transfer in corneas treated with gene therapies incorporating plasmid vectors and does not produce as much inflammation as seen with other gene transfer methods.

Kathleen Blair-Parks,...

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Source: Gene Therapy Weekly (2002-02-21)

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