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Cancer Vaccines

Cytokine Immunizations Work Better When Local Tumor Irradiation Included

Published in Gene Therapy Weekly, February 21st, 2002

by Sonia Nichols, senior medical writer - Cell factor vaccines that can prevent the growth of gliomas work better when the tumors are also treated with local radiotherapy, medical researchers in Hungary suggest.

Glioma cells (Gl261) transduced with genes for a number of cytokines worked well when administered as vaccines to tumor-implanted mice, but they worked even better when immunization was accompanied by local tumor irradiation, according to K. Lumniczky and colleagues, National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary. Since radiotherapy is often a primary or secondary treatment method for brain tumors such as gliomas, adding...

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