Endocrinology

Long-distance command sends vital human growth hormone into action

Published in Gene Therapy Weekly, March 28th, 2002

Scientists have long sought to determine what agent controls the production of the human growth hormone hGH, which is vital for proper physical development.

Now, in findings that point toward an eventual gene therapy for the type of dwarfism that results when the pituitary gland is unable to manufacture the hormone, scientists at the University of Pennsylvania School of Medicine have found the mechanism that sets hGH in action. In addition, they've discerned an unusual pattern of activation in which the key mechanism operates by remote control. Their research appeared in the February 15, 2002 issue of the journal Molecular Cell.

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Source: Gene Therapy Weekly (2002-03-28)

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