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Genetic Engineering

New method used to transfer genes into mouse

Published in Gene Therapy Weekly, May 2nd, 2002

For the first time, a special segment of DNA called a transposon and an enzyme known as the Sleeping Beauty transposase have been used to genetically modify a vertebrate animal. In the study, which is published in the April 2, 2002, issue of the Proceedings of the National Academy of Sciences USA, University of Minnesota researchers injected a transposon containing the gene for a yellow coat color into a mouse embryo, resulting in a genetically modified mouse.

"This is a new type of technology, an entirely different way to make genetically modified animals," said David Largaespada, PhD, an assistant professor in the university's department of genetics, cell...

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