Diabetic Retinopathy

Angiopoietin-1 reverses leukocyte adhesion in retinas of diabetic model

Published in Gene Therapy Weekly, June 20th, 2002

by Sonia Nichols, senior medical writer - Scientists have been able to reverse leukocyte adhesion and vascular breakdown in the retinas of newly diabetic rats and mice with established diabetes by using local and systemic treatments of angiopoietin-1.

Diabetic retinopathy is an important diabetes complication that can cause blindness if left unchecked. When it develops, leukocytes adhere to blood vessels within the retina, causing them to leak and form lesions. Angiopoietin-1 is a natural protein that has been shown to stabilize vascular remodeling. According to a research team led by Harvard Medical School investigators, angiopoietin-1 therapy, whether administered...

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Source: Gene Therapy Weekly (2002-06-20)

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