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Reproductive Technology

Gene therapy reverses infertility in male mice

Published in Gene Therapy Weekly, June 20th, 2002

A team led by Salk Institute scientists has used gene therapy to reverse infertility in male mice.

Treated mice produced healthy offspring that did not contain the introduced gene or vector, alleviating concerns that treating infertility via gene therapy would genetically alter any progeny produced from the treatment, as well as their descendants in perpetuity.

About one out of every five couples worldwide experience fertility problems, and one-third to one-half of these cases result from male infertility.

"The overwhelming majority of male infertility cases arise from inability to make sperm cells," said Inder Verma, a professor...

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