Ovarian Cancer

Receptor makes cells more amenable to uptake of virus-mediated gene therapy

Published in Gene Therapy Weekly, June 27th, 2002

by Sonia Nichols, senior medical writer - The way cells targeted by gene therapies take up viral delivery systems can make or break the effectiveness of the therapy. One way to enhance the sensitivity of ovarian cancer cells to adenovirus-based delivery mechanisms is to increase CAR (coxsackievirus and adenovirus receptor) expression, according to a multicenter Korean study.

"CAR is known to be a primary receptor for attachment during adenovirus infection of target cells and thus is closely related to adenoviral infection efficiency," commented Jong-Sik Kim, an investigator at Sunkyunkwan University in Seoul, Korea.

Kim and colleagues at Kyungpook...

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Source: Gene Therapy Weekly (2002-06-27)

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