Skin Cancer

Unexpected findings leave role of COX-2 in cancer formation unexplained

Published in Gene Therapy Weekly, June 27th, 2002

by Sonia Nichols, senior medical writer - Laboratory mice bred to produce high levels of cyclooxygenase (COX)-2 not only become bald, but they also become protected from skin cancer, new evidence indicates.

Seeking to establish how COX-2 may modulate tumor formation, researchers have been surprised to find that COX-2 may actually contribute to tumor suppression, according to a new report in Cancer Research.

"To better understand the role of COX-2 in tumorigenesis, we generated transgenic mice that overexpress COX-2 under control of the human keratin 14 promoter, which allows for expression in the epidermis and some other epithelia," David K....

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Source: Gene Therapy Weekly (2002-06-27)

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