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Lung Cancer

Certain retinoids able to override nicotine effects better than others

Published in Gene Therapy Weekly, July 25th, 2002

by Sonia Nichols, senior medical writer - Clinical trials suggesting that common retinoids have little value for overriding the effects of nicotine in cigarette smokers may have been using the wrong type of retinoids, according to researchers at a major cancer research center.

Investigators at the Burnham Institute Cancer Center in La Jolla, California, recently suggested that RXR [rentinoid X receptor]-selective retinoids, rather than classical retinoids, may be able to overcome nicotine-related inhibition of tumor suppression, tumor providing a novel way to treat or prevent lung cancer.

In preliminary studies of lung cancer, G.Q. Chen and...

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