Cholesterol

Restenosis arising from stent placement mitigated with gene transfer

Published in Gene Therapy Weekly, August 22nd, 2002

by Sonia Nichols, senior medical writer - Arterial lesions arising from neointimal formation after stent placement might be prevented with the use of gene transfer techniques, scientists are predicting.

High cholesterol levels are a major contributing factor to arterial occlusion. Hypercholesterolemic rabbits used in gene therapy experiments show that I kappa B alpha (inhibitor of nuclear factor kappa B (NF-kappaB)), may prevent neointimal formation and restenosis after stent implantation.

In the study, Manfred Cejna and colleagues, Vienna Medical School, Vienna, Austria, administered local treatments of adenovirus encoding for I kappaB alpha to...

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Source: Gene Therapy Weekly (2002-08-22)

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