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Brain Injury

Gene construct reduces inflammatory reaction in traumatically injured brains

Published in Gene Therapy Weekly, September 12th, 2002

by Sonia Nichols, senior medical writer - Brains that suffer traumatic injury could potentially be treated with a newly developed adenoviral construct with deleted coding, according to researchers in Houston, Texas.

Though gene therapy has the potential for treating traumatic brain injury (TBI), virus-based delivery vehicles typically ignite inflammatory response mechanisms and in some instances can be cytotoxic, hampering gene therapy effectiveness, according to Linglong Zou and colleagues, Baylor College of Medicine, Houston, Texas.

Zou and coauthors have developed a less immunogenic gene delivery system composed of an adenoviral construct missing...

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