Published in Gene Therapy Weekly, October 17th, 2002
In one of the first studies of its kind, researchers in the United Kingdom have demonstrated lentiviral vectors can successfully transfer genes to human heart muscle cells, or cardiomyocytes.
Human immunodeficiency virus (HIV) type 1 is a lentivirus. Using pseudotyped HIV-1, Zing Zhao and colleagues, University of Cambridge, have developed constructs containing reporter genes and other genetic materials, testing the constructs for transfer efficiency both in vitro and in vivo.
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