Cancer Pain

Pain control possible with gene therapy

Published in Gene Therapy Weekly, November 14th, 2002

By "programming" a herpes simplex virus to deliver a gene-mediated pain-blocking protein at the cellular level, University of Pittsburgh researchers have been able to significantly reduce cancer-related pain in mice with tumors.

Their report, "Herpes vector-mediated expression of proenkephalin reduces bone cancer pain," is available online the web site for Annals of Neurology (www.interscience.wiley.com/jpages/0364-5134).

"Chronic pain is notoriously difficult to treat effectively," said coauthor Joseph Glorioso, PhD, chairman of the department of molecular genetics and biochemistry and director of the Molecular Medicine Institute at the...

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Source: Gene Therapy Weekly (2002-11-14)

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