HIV/AIDS Gene Therapy
Protein chimera can block viral replication
Published in Gene Therapy Weekly, November 14th, 2002
"The human cyclin T1 (hCycT1) protein from the positive transcription elongation factor b (P-TEFb) binds the transactivator Tat and the transactivation response (TAR) RNA stem loop from human immunodeficiency virus type 1 (HIV)," explained Koh Fujinaga and colleagues at the University of California at San Francisco.
Fujinaga and coauthors found that a dominant-negative fusion protein, comprising mutant versions of hCycT1 and TAR (Cdk9), strongly inhibited HIV activity in human...
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Source: Gene Therapy Weekly (2002-11-14)
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