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Virology

Purdue corrals new Trojan horse to replace wayward genes in mice

Published in Gene Therapy Weekly, November 21st, 2002

A research team at two Midwest U.S. universities has developed a new way to genetically alter cells in living mice, offering new possibilities in the war against cancer and other diseases.

Using a modified virus as a Trojan horse, a team led by Purdue University's David Sanders has found a promising system to deliver genes to diseased liver and brain cells. By placing helpful genetic material within the outer protein shell of Ross River virus (RRV), Sanders' team was able to alter the mice's liver cells without producing the harmful side effects that have accompanied the use of other retroviruses.

"This represents a major advance in that we have...

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