Pulmonary Medicine

Hepatocyte growth factor gene transfer induces angiogenesis in rat lung

Published in Gene Therapy Weekly, December 12th, 2002

According to a report from Japan, "Recent studies have demonstrated that gene transfer with hepatocyte growth factor (HGF) induces angiogenesis for coronary and peripheral artery diseases. We investigated the ability of gene transfer with human HGF to induce angiogenesis in the rat lung."

"The left lung was selectively transfected with a cDNA encoding human HGF via the left pulmonary artery, using the HVJ-liposome method (H group); rats transfected with the same vector lacking the HGF gene served as controls (C group)," explained M. Ono and colleagues, Osaka University.

"HGF gene transfer significantly increased the capillary density in the left...

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Source: Gene Therapy Weekly (2002-12-12)

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