Drug Resistance
Gene transfer sensitizes liver cancer cells to chemotherapy
Published in Gene Therapy Weekly, December 12th, 2002
It is not uncommon for cancers to become drug-resistant at some point during chemotherapy, according to Matthes Huesker and colleagues, University Hospital Freiburg, Freiburg, Germany.
"The multidrug resistance (MDR) transporters MDR1-P-glycoprotein and MRP2 (multidrug-associated protein 2) are expressed in almost 50% of human cancers, including hepatocellular carcinomas (HCCs)," Huesker and coauthors explained in Hepatology.
The researchers...
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Source: Gene Therapy Weekly (2002-12-12)
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