Published in Gene Therapy Weekly, December 19th, 2002
Wayne State University, Michigan, cancer researchers demonstrated this by developing vectors responsive to both hypoxia and ionizing radiation (IR).
"Gene expression was regulated by novel, synthetic promoters containing hypoxia responsive elements (HREs) from the erythropoietin (Epo), the phosphoglycerate kinase 1 (PGK1), and the vascular endothelial growth factor (VEGF) genes, and IR-responsive CArG elements from the early growth response...
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