Genetic Modification

Technique efficiently alters hair shaft phenotype

Published in Gene Therapy Weekly, December 19th, 2002

Researchers with AntiCancer Inc., San Diego, California, have developed a "technique for genetic modification of hair follicles ... [that] results in efficient alteration of the hair shaft phenotype."

According to N. Saito and colleagues, "[h]igh-level in vivo transgene expression was maintained in hair follicles such that growing hair shafts were phenotypically altered. Mouse anagen skin fragments, maintained in histoculture, were genetically modified at high efficiency with adenoviral-GFP.

"The histocultured skin fragments were treated with collagenase, which made hair follicles accessible to the adenoviral GFP gene, allowing high-efficiency...

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Source: Gene Therapy Weekly (2002-12-19)

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