Hepatic Ischemic Reperfusion Injury
Antisense oligonucleotide for tissue factor inhibits damage to liver
Published in Gene Therapy Weekly, December 19th, 2002
"Tissue factor (TF) is an initiation factor for blood coagulation and its expression is induced on endothelial cells during inflammatory or immune responses. We designed an antisense oligodeoxynucleotide (AS-1/TF) for rat TF and studied its effect on hepatic ischemic reperfusion injury," stated K. Nakamura and colleagues, Kyoto Prefectural University of Medicine.
The researchers administered AS-1/RF to Lewis rats intravenously. Then, 10 hours later, "the hepatic artery and portal vein were partially clamped. Livers were...
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Source: Gene Therapy Weekly (2002-12-19)
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