Glioma

Herpes simplex virus gene therapy shows promise for treating brain cancer

Published in Gene Therapy Weekly, December 19th, 2002

by Sonia Nichols, senior medical writer - Repeated intratumoral delivery of adenovirus-mediated herpes simplex virus thymidine kinase (a/tk) gene therapy may be the optimal approach for treating glioma.

That is the finding of researchers at the University of Kuopio in Finland, who compared the effects of several different gene therapy regimens in syngeneic BT4C rat malignant glioma models.

According to Kristiina Tyynela and colleagues, they placed eight different groups of rats on eight different treatment protocols comprising ad/tk, ganciclovir (GCV), adv-mediated macrophage colony-stimulating factor (adv/MCSF) or no treatment at all. They...

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Source: Gene Therapy Weekly (2002-12-19)

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