Atherosclerosis

Apolipoprotein A-I no helpmate for cholesterol gene therapy

Published in Gene Therapy Weekly, December 19th, 2002

by Sonia Nichols, senior medical writer - Apolipoprotein A-I overexpression may not be able to overcome atherosclerosis in situations where hypercholesterolemia prevails.

The new finding was reported in Atherosclerosis by researchers who work at the University of Pennsylvania in Philadelphia.

Apolipoprotein A-I (apoA-I) is a constituent of high-density lipoprotein and alleviates the formation of arterial blockage in animals with high cholesterol levels, according to D.J. Rader and colleagues. However, new experiments have demonstrated using apoA-I gene therapy in conjunction with cholesterol lowering gene therapy fails to yield significant...

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Source: Gene Therapy Weekly (2002-12-19)

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