Gene Transfer

Pseudotyped vectors suitable for stem cell applications

Published in Gene Therapy Weekly, December 26th, 2002

by Sonia Nichols, senior medical writer - Vectors derived from human packaging cell lines outpace those produced by murine packaging cell lines for generating transduction stability and multilineage activity in hematopoietic stem cells, researchers say.

Scientists in Seattle, Washington, have developed such a vector and tested its efficacy in animals for more than a year. Their findings indicate the vector would be suitable for therapies combining gene transfer with stem cell implantation.

"We generated a human packaging cell line with a gibbon ape leukemia virus pseudotype (Phoenix-GALV), and we evaluated vectors produced by Phoenix-GALV for their...

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Source: Gene Therapy Weekly (2002-12-26)

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