Melanoma

One source of CTL-targeted antigens identified

Published in Gene Therapy Weekly, December 26th, 2002

Geneticists in Belgium report that they've "identified a gene encoding an antigen recognized by cytolytic T lymphocytes on the autologous tumor cells of a melanoma patient," and that this could serve as the basis for a vaccine.

F. Schiavetti and colleagues, University Catholique Louvain, said, "The gene shows homologies with members of the HERV-K family of human endogenous retroviruses, and it was provisionally named HERV-K-MEL. It contains many mutations that disrupt the open reading frames coding for all of the viral proteins."

"The HERV-K-MEL gene is not expressed in normal tissues with the exception of testis and some skin samples. It is...

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Source: Gene Therapy Weekly (2002-12-26)

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