Pancreatic Cancer

Intraperitoneal transduction of Ad-NK4 curbs peritoneal dissemination in mice

Published in Gene Therapy Weekly, December 26th, 2002

Intraperitoneal transduction of adenovirus-mediated NK4 gene suppressed development of tumor nodules in a nude mouse model of peritoneal dissemination of pancreatic cancer.

Writing in Cancer Gene Therapy, M. Saimura and colleagues, Kyushu University, Japan, said, "NK4, composed of the N-terminal hairpin and subsequent four-kringle domains of hepatocyte growth factor (HGF), acts not only as a competitive antagonist for HGF but aIso as a potent angiogenesis inhibitor. This study was designed to assess a therapeutic potential of adenovirus-mediated NK4 gene transfer for disseminated pancreatic cancer cells in the peritoneal lavage of nude mice."

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Source: Gene Therapy Weekly (2002-12-26)

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