Heart Failure

Hepatocyte gene therapy aids healing of failing hearts

Published in Gene Therapy Weekly, December 26th, 2002

by Sonia Nichols, senior medical writer - Dogs with failing hearts benefit from hepatocyte gene therapy. Humans with failing hearts could do so as well.

Researchers have used hepatocyte growth factor gene therapy to improve cardiac function in a rapid pacing-induced heart failure canine model. They contend the novel gene therapy demonstrates potential for treating human heart failure.

According to Ismayil Ahmet and coauthors, Osaka University Medical School, Osaka, Japan, hepatocyte growth factor is known to increase angiogenesis and staunch apoptosis and fibrosis. The gene therapy, containing a hemagglutinating virus of Japan (Sendai virus)...

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Source: Gene Therapy Weekly (2002-12-26)

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