Developmental Biology
Morpholino antisense oligonucleotides used to target embryonic gene expression
Published in Gene Therapy Weekly, January 2nd, 2003
"Morpholino antisense oligonucleotides act by blocking translation of their target gene products and are effective tools for downregulating gene expression," said L.S. Siddall and colleagues, University of Western Ontario, who conducted a study "to define treatment conditions for the use of morpholino oligonucleotides (MOs) in mammalian preimplantation embryos, and to employ MOs to target genes and study gene function in the early embryo."
The researchers said, "For the first time, ethoxylated...
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Source: Gene Therapy Weekly (2003-01-02)
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