Malignant Mesothelioma

Ad-IFN gamma induces antiproliferative and antitumoral responses

Published in Gene Therapy Weekly, January 2nd, 2003

Researchers in France investigated "the effects of adenovirus (Ad)-mediated IFN-gamma gene transfer on human mesothelioma (HM) cell proliferation in vitro and growth in nude mice."

F. Gattacceca and colleagues, University of Paris, "constructed an E1E3-deleted replication-defective recombinant Ad carrying the human IFN-gamma gene (Ad-IFN-gamma) and tested its activity in vitro on HM cell lines established in [their] laboratory and in a nude mice model."

The researchers found that "in vitro, infection of HM cells with Ad-IFNgamma led to a prolonged production of an active cytokine in the 10 HM cell lines tested and also led to an antiproliferative...

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Source: Gene Therapy Weekly (2003-01-02)

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