Insulin Resistance

Tumor necrosis factor blockade may prevent metabolic meltdown

Published in Gene Therapy Weekly, January 9th, 2003

by Sonia Nichols, senior medical writer - After continued exposure to high levels of the cytokine tumor necrosis factor (TNF)-alpha, genes in fat cells begin performing erratically and start expressing factors associated with insulin resistance.

Researchers at the Massachusetts Institute of Technology suspect that controlling TNF-alpha would be one way to contain TNF-alpha-induced insulin resistance.

A study of TNF-alpha infusion on gene expression and transcription in adult rodents has produced a clearer picture of its effects on metabolism, according to Hong Ruan and colleagues. The researchers conducted their studies at the Whitehead Institute...

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Source: Gene Therapy Weekly (2003-01-09)

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