Cancer Gene Therapy

Novel adenovector with a radiation-inducible promoter reduces TNFalpha toxicity

Published in Gene Therapy Weekly, January 16th, 2003

GenVec Inc. researchers have developed a "second-generation (E1-, E3-, and E4-deleted) replication-deficient adenovector carrying the transgene encoding for human tumor necrosis factor alpha (TNFalpha), regulated by the radiation-sensitive promoter Early Growth Response (Egr-1)." They call it TNFerade Biologic.

H. Rasmussen and colleagues wrote that they "hypothesized that intratumoral injection of TNFerade followed by radiation would result in potentially therapeutic levels of TNFalpha with minimal toxicity. Three preclinical studies were conducted, the purpose of which was to characterize the toxicity and pharmacokinetics of TNFerade in conjunction with radiation in...

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Source: Gene Therapy Weekly (2003-01-16)

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