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Gene Cleaving

Enzymatic RNA works better when complexed with polymer

Published in Gene Therapy Weekly, January 16th, 2003

by Sonia Nichols, senior medical writer - Ribozymes have the power to cleave genetic molecules before proteins can be produced.

However, ribozymes, RNA with enzymatic properties, tend to be unstable. Scientists in Germany may have found a feasible way to override that instability.

The scientists work at Phllips-University Marburg in Marburg, Germany, where they have generated ribozymes that are complexed with low-molecular-weight polyethyleneimine (LMW-PEI). According to researchers, the ribozyme/LMW-PEI constructs have an unparalleled ability to target protein construction with stability and specificity.

"LMW-PEI almost...

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