Osteogenesis
Ex vivo bone morphogenetic protein-9 gene therapy induces spinal fusion in rats
Published in Gene Therapy Weekly, January 16th, 2003
"Ex vivo gene therapy with the use of human mesenchymal stem cells (hMSCs) and bone morphogenetic protein (BMP) genes provides a local supply of precursor cells and a supraphysiological dose of osteoinductive molecules that may promote bone formation in patients with inadequate hMSC populations, because of age, osteoporosis, metastatic bone disease, iatrogenic depletion, or other metabolic derangements," according to University of Virginia neurologists.
R.J. Dumont and colleagues evaluated "the efficacy of ex vivo gene therapy with the use of hMSCs and the BMP-9 gene to promote spinal fusion in the rat."
"Sixteen athymic nude rats were treated with...
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Source: Gene Therapy Weekly (2003-01-16)
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