Pediatric Vaccine

Robust immune response to DNA vaccine found in infants

Published in Gene Therapy Weekly, January 23rd, 2003

by Maria G. Essig, MS, ELS, senior medical writer - Neonates mounted an antigen-specific CD8+ T cell response to a DNA vaccine encoding a peptide antigen, according to a report in the Journal of Virology.

"Neonates are thought to mount less vigorous adaptive immune responses than adults to antigens and infectious agents," commented Jie Zhang and colleagues at the Scripps Research Institute in La Jolla, California. "This concept has led to a delay in the administration of many currently available vaccines until late infancy or early childhood."

Zhang and collaborators cited previous studies in which vaccination of infants soon after birth with...

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Source: Gene Therapy Weekly (2003-01-23)

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