Restenosis
Nanospheres loaded with antisense particles prevent stenotic recurrence
Published in Gene Therapy Weekly, January 30th, 2003
According to a study from Germany, "nanospheres composed of the biocompatible and biodegradable polymer, poly-DL-lactide/glycolide and containing platelet-derived growth factor beta-receptor antisense (PDGFbetaR-AS) have been formulated and examined in vitro and in vivo in balloon-injured rat restenosis model. The nanospheres (approximately 300 nm) of homogenous size distribution exhibited high encapsulation efficiency (81%), and a sustained release of PDGFbetaR-AS (phosphorothioated). Cell internalization was visualized, and the inhibitory effect on SMC was observed."
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Source: Gene Therapy Weekly (2003-01-30)
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