Diabetic Nephropathy

JAK/STAT signaling pathway implicated in diabetes-linked complication

Published in Gene Therapy Weekly, January 30th, 2003

Researchers have indicted the JAK/STAT signaling pathway in kidney complications arising from diabetes.

According to researchers from the United States, "High glucose (HG) causes glomerular mesangial cell (GMC) growth, production of transforming growth factor (TGF)-beta, and increased synthesis of matrix proteins such as fibronectin, contributing to diabetic nephropathy. We recently found that exposure of cells to HG also activates the growth-promoting enzyme janus kinase 2 (JAK2) and its latent signal transducers and activators of transcription (STAT) transcription factors (STAT1, STAT3, and STAT5)."

"Our purpose was to determine the effect that...

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Source: Gene Therapy Weekly (2003-01-30)

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