Published in Gene Therapy Weekly, February 6th, 2003
According to a new study, "an effective immune response against cancer requires the activation and expansion of specific T cells. Tumor antigens, however, are generally poor immunogens. To achieve expansion of tumor-reactive T cells in vivo, we used a strategy of generating dual-specific T cells that could respond to a powerful immunogen while also possessing tumor reactivity."
"We generated dual-specific T cells by genetic modification of alloreactive T cells with a chimeric receptor recognizing...
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