Cancer Vaccine

Dual-specific T cells knock out tumors with double punch

Published in Gene Therapy Weekly, February 6th, 2003

Immune system cells genetically redesigned to recognize immunogen show promise for treating cancer, United States government researchers indicate.

According to a new study, "an effective immune response against cancer requires the activation and expansion of specific T cells. Tumor antigens, however, are generally poor immunogens. To achieve expansion of tumor-reactive T cells in vivo, we used a strategy of generating dual-specific T cells that could respond to a powerful immunogen while also possessing tumor reactivity."

"We generated dual-specific T cells by genetic modification of alloreactive T cells with a chimeric receptor recognizing...

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Source: Gene Therapy Weekly (2003-02-06)

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