Cell Receptors

Ephrin mimetic peptide could select for EphA2 receptor in many diseases

Published in Gene Therapy Weekly, February 6th, 2003

Researchers have discovered ephrin mimetic peptides might be effective drug delivery agents for the treatment of a number of different diseases.

"Eph receptor tyrosine kinases represent promising disease targets because they are differentially expressed in pathologic versus normal tissues. The EphA2 receptor is up-regulated in transformed cells and tumor vasculature where it likely contributes to cancer pathogenesis. To exploit EpbA2 as a therapeutic target, we used phage display to identify two related peptides that bind selectively to EphA2 with high affinity (submicromolar K-D values)," researchers in the United States reported.

"The peptides...

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Source: Gene Therapy Weekly (2003-02-06)

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