Published in Gene Therapy Weekly, February 6th, 2003
According to a study from France, "upstream activating sequences of the rat aldolase C gene are shown here to confer brain-specific expression in transgenic mice. In addition to binding sites described previously for the brain-expressed POU proteins Brn-1 and Brn-2 (Skala, H., et.al. J Biol Chem, 1998;273:31806-31814), we have identified two novel DNA elements critical for an interaction with a brain-specific, high affinity DNA-binding protein.
"Characterization of this binding protein showed it to be sensitive to thiol oxidation and stable to heat at 100 degrees C. ...
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