Microvessel Physiology
Akt signaling mediates VEGF/VPF vascular permeability in vivo
Published in Gene Therapy Weekly, February 13th, 2003
"VEGF is an endothelial cell cytokine that promotes angiogenesis and enhances microvascular permeability. Recently, it has been shown that the protein kinase Akt functions in a key intercellular signaling pathway downstream of VEGF. Here, we employed adenovirus-mediated gene transfer in conjunction with the Miles assay in hairless albino guinea pigs to assess the role of Akt signaling in vascular permeability," researchers in the United States said.
"VEGF-induced vascular permeability was blocked by the...
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Source: Gene Therapy Weekly (2003-02-13)
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