Prostate Cancer
MDM2 oncogene inhibitors show broad range of anticancer activity
Published in Gene Therapy Weekly, February 13th, 2003
According to Hui Wang and colleagues at the University of Alabama at Birmingham, prostate cancer and many other cancers overexpress MDM2 oncogene. However, MDM2 antisense oligonucleotides can prevent prostate cancer growth even when p53 expression is not normal.
In their study Wang and coauthors treated three prostate cancer cell lines and murine xenografts with antisense anti-human-MDM2 mixed backbone oligonucleotide. They also treated the cells and...
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Source: Gene Therapy Weekly (2003-02-13)
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