Transgenic Medicine
Distal regulatory elements needed for selective expression of interferon-gamma
Published in Gene Therapy Weekly, February 13th, 2003
"Using a transgenic approach, we analyzed the contribution of introns located within the IFN-gamma gene and distal regulatory regions to IFN-gamma gene expression. Intron 1 and 3 from the IFN-gamma gene displayed strong enhancer activity. This activity appeared to be dependent upon integration into the genome but resulted in a loss of Th1 selectivity," wrote M. Soutto and colleagues, Vanderbilt University, Medical Center.
"We also found that distal regulatory elements are not required for high level expression of the human IFN-gamma...
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Source: Gene Therapy Weekly (2003-02-13)
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