Published in Gene Therapy Weekly, February 27th, 2003
"Gene silencing via promoter CpG island hypermethylation offers tumor cells growth advantages. This epigenetic event is pharmacologically reversible, and uncovering a unique set of methylation-silenced genes in tumor cells can bring a new avenue to cancer treatment. However, high-throughput tools capable of surveying the methylation status of multiple gene promoters are needed for this discovery process," wrote H.D. Shi and colleagues, University of Missouri, Ellis Fischel Cancer Center.
"Herein we describe...
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