Transfection

High mobility group proteins are involved in DNA integration

Published in Gene Therapy Weekly, February 27th, 2003

According to recent research from Japan, "high mobility group 1 and 2 proteins (HMGB 1 and HMGB2) are abundant chromosomal proteins in eukaryotic cells. We examined the involvement of HMGB1 and HMGB2 in nonhomologous illegitimate recombination."

"The HMGB I or HMGB2 expression plasmid, carrying the neo' gene as a selection marker, was introduced into HeLa S3 cells to obtain stably-transfected cells," explained T. Ueda and colleagues, Science University Tokyo, Department of Biological Science and Technology.

"The number of G418-resistant colonies was about 10 times the number of colonies of control cells transfected with plasmids not carrying the...

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Source: Gene Therapy Weekly (2003-02-27)

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