Published in Gene Therapy Weekly, March 13th, 2003
"Control of gene expression is a cherished goal of cancer chemotherapy. Small ligand molecules able to bind tightly to DNA in a well-defined configuration are being actively searched for. With this goal in mind, we have designed and synthesized the trifunctional molecule R-132, which combines a bispyrrole skeleton for minor groove DNA recognition and two different chromophores, anilinoacridine and ethidium," wrote C. Carrasco and colleagues, University of Paris 05, Faculty of Pharmaceutical & Biological Science.
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