Glioblastoma
Bispecific antisense treatment downregulates genes in cancer cells
Published in Gene Therapy Weekly, March 13th, 2003
"The functions of the antiapoptotic proteins Bcl-2 and Bcl-xL were examined in glioblastoma cells. Expression of both Bcl-2 and Bcl-xL were found to be elevated in protein lysates from seven early passage cell lines derived from human glioblastoma tumors compared with non-neoplastic glial cells," said Z.H. Jiang and colleagues, Washington University, School of Medicine.
"Downregulation of both bcl-2 and bcl-xL expression in glioblastoma cell lines U87 and NS008 with bcl-2/bcl-xL bispecific antisense oligonucleotide resulted in spontaneous cell death," they...
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Source: Gene Therapy Weekly (2003-03-13)
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