Ophthalmology
Transfected retinal explants offer a new way to explore neural formation
Published in Gene Therapy Weekly, March 13th, 2003
"Neural retina can be isolated from mouse embryos and maintained in culture for 2-3 weeks. In such retinal explant cultures, precursor cells differentiate into neurons and glial cells and form three cellular layers, mimicking well the normal development. This explant culture system is suitable for genetic manipulation, such as retrovirus-mediated gene transfer," researchers in Japan report.
"Retroviral vectors can efficiently transfer genes into retinal precursors, and the copy of the viral genome is precisely transmitted to the progeny of infected cells," wrote J. Hatakeyama...
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Source: Gene Therapy Weekly (2003-03-13)
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