Oncology
Antisense p53 transduction lessens apoptosis in multiple myeloma
Published in Gene Therapy Weekly, March 20th, 2003
According to recent research from the United States, "multiple myeloma is a malignant proliferation of plasma cells which fail to undergo apoptosis. To understand events associated with lack of apoptosis in these cells, we studied effect of antisense p53 gene transduction in a multiple myeloma cell line, ARH77."
"Adeno-associated virus was used as a vector to introduce p53 cDNA in an antisense orientation driven by a herpes virus thymidine kinase promoter," stated R. Iyer and colleagues, Dana Farber Cancer Institute.
"We observed, that an antisense p53 (p53as)...
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Source: Gene Therapy Weekly (2003-03-20)
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