Brain Cancer
Dexamethasone inhibits the antitumor effect of interleukin 4 in rodent glioma
Published in Gene Therapy Weekly, March 20th, 2003
According to a study from Italy, "retroviral-mediated gene transfer of the IL-4 gene into experimental gliomas can cause tumor rejection, supporting the clinical use of this form of gene therapy for glioblastomas (GBM). In a clinical setting, the administration of dexamethasone (dex) is a standard procedure for GBM patients. This led us to examine the effects of dex on IL-4 gene therapy."
"We injected intracranially Fischer 344 rats with phosphate-buffered saline, 9L gliosarcoma cells mixed with E86.L4SN(200) cells (retroviral producer cells, (RPC), transducing IL-4...
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Source: Gene Therapy Weekly (2003-03-20)
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