Vaccinology
A new immunogene vaccine blocks enzyme-associated tumor proliferation
Published in Gene Therapy Weekly, March 27th, 2003
"Matrix metalloproteinase (MMP) family, in particular MMP-2, may play a key role in angiogenesis and tumor growth. It is conceivable that the breaking of immune tolerance of MMP-2 should be a useful approach to cancer therapy by active immunity. To test this concept, we constructed a plasmid DNA encoding chicken homologous MMP-2 (c-MMP-2) and control vectors," researchers in the People's Republic of China reported.
"We found that the vaccine based on chicken homologous MMP-2 as a model antigen could induce both protective and therapeutic antitumor immunity. Autoantibodies...
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Source: Gene Therapy Weekly (2003-03-27)
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